The Luker Lab, Molecular Imaging of Signaling in Cancer

The Luker lab studies functions of cell signaling in primary and metastatic cancer.  Our multidisciplinary group combines expertise in medicine, biology, and engineering to uncover the mechanisms by which biochemical events in the tumor microenvironment, including chemokine signaling, metabolic regulation, and extracellular matrix interactions regulate the disease progression and response to therapy. 

Our lab is located within the Center for Molecular Imaging at the University of Michigan, Ann Arbor.  As experts in the field of molecular imaging, our research takes advantage of technologies such as bioluminescence and multiphoton fluorescence imaging in living systems to visualize the impact of signaling events in real time.  We are always developing new biological and engineering solutions for visualizing these processes.  In particular, we are developing methods in fluorescence lifetime imaging and multispectral bioluminescence to extend our optical imaging capabilities.  

Our close collaborators are crucial to our research program.  A sampling of our collaborators includes: 

the Shu Takayama lab, in Biomedical Engineering at University of Michigan, who develop microfluidic approaches to modeling organ systems. 

the Jennifer Linderman lab, in Chemical Engineering at University of Michigan, who apply systems biology computational modeling to understand the behavior of biological networks.

the Euisik Yoon lab in Electrical Engineering and Computer Science, who along with Yu-Chih Chen develop self-contained microsystems that combing and process natural signals and electrical signals on a single chip platform.  

the Max Wicha lab in the University of Michigan Comprehensive Cancer Center, who are experts in the study of cancer stem cells.

the Dan Hayes lab in  the University of Michigan Comprehensive Cancer Center, who are experts in the study and treatment of breast cancer. 

the Joerg Lahann lab in Chemical Engineering, who perform research in surface engineering, advanced polymers, biomimetic materials, tissue engineering and nanoscale technologies.