Illuminating biochemical and cellular behavior in living systems

The Luker lab studies  functions of chemokine receptor signaling in primary and metastatic cancer.  Our multidisciplinary group combines expertise in medicine, biology, and engineering to  uncover the mechanisms by which chemokine receptors, such as CXCR4 and CXCR7, and their ligands, such as CXCL12, regulate the tumor environment and impact disease outcomes.  

Our lab is located within the Center for Molecular Imaging at the University of Michigan, Ann Arbor.  As experts in the field of molecular imaging, our research takes advantage of technologies such as bioluminescence and multiphoton fluorescence imaging in living systems to visualize the impact of signaling events in real time.  We are always developing new biological and engineering solutions for visualizing these processes.  In particular, we are developing methods in fluorescence lifetime imaging and multispectral bioluminescence to extend our optical imaging capabilities.  

Our close collaborators are crucial to our research program.  A sampling of our collaborators includes: 

the Shu Takayama lab, in Biomedical Engineering, who develop microfluidic approaches to modeling organ systems. 

the Jennifer Linderman lab, in Chemical Engineering, who apply systems biology computational modeling to understand the behavior of biological networks.

the David Blaauw and Dennis Sylvester labs, in EECS, who develop implantable microelectronic devices to continuously monitor physiologic events in live mice.